Cushing Syndrome (also known as Cushing's Syndrome and Hypercortisolism) is caused by an influx of cortisol that comes from something either inside or outside of the body. This means the excessive cortisol could be caused by a pituitary or adrenal tumour, or by corticosteroid medications such as prednisone. Cushing Syndrome can also occur when the body produces too much cortisol on its own.
Cushing Disease is a specific form of Cushing Syndrome and is the result of the body producing too much cortisol. Cortisol is a hormone that is related to the body's stress response and its secretion is controlled by the hypothalamus, the pituitary gland, and the adrenal gland. Cushing Disease is considered a rare pituitary disorder. It effects 10 to 15 people per million each year and is most commonly found in adults between the ages of 20-50 years old and 70% of cases are women. This type of Cushing Syndrome is caused by a pituitary tumour that produces too much much cortisol. Without treatment, symptoms will get worse as this disease is considered progressive. However, with treatment, symptoms can be managed, elevated to an extent, and those with Cushing Disease (or Cushing's Disease) can lead healthy and active lives.
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